Answer:
Let's break down the expression step by step:
1. Calculate the innermost expression within the curly braces:
\[2 \times (-25) \div (-5) = -50 \div (-5) = 10.\]
2. Next, calculate the expression within the square brackets:
\[(-216) \div 8 = -27.\]
3. Now, apply the result from step 1 to the expression within the curly braces:
\[(-27) \times 10 = -270.\]
4. Finally, calculate the expression within the parentheses:
\[\frac{(-72) \div (-3)}{(-2) + (-6)} = \frac{24}{-8} = -3.\]
5. Apply the result from step 4 to the result from step 3:
\[-3 \times -270 = 810.\]
So, the final answer is \(810\).